Motif ID: NANOG{mouse}.p2

Z-value: 0.952


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_79420250.125.3e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_25055228 3.843 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_-_52567809 3.396 NT5DC2
5'-nucleotidase domain containing 2
chr3_-_52567708 3.156 NM_001134231
NT5DC2
5'-nucleotidase domain containing 2
chr1_-_28520379 3.006 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr6_+_151561094 2.919 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_2096930 2.777 IZUMO4
IZUMO family member 4
chr6_+_34204647 2.375 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr6_+_34204663 2.333 HMGA1
high mobility group AT-hook 1
chr8_-_91094924 2.199 NM_004929
CALB1
calbindin 1, 28kDa
chr6_+_34204576 1.931 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr6_+_34205029 1.855 HMGA1
high mobility group AT-hook 1
chr12_-_123187842 1.808 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr15_-_31947541 1.682 NM_130901
OTUD7A
OTU domain containing 7A
chr6_-_30652434 1.681 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr8_+_22022644 1.666 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr7_+_134576187 1.610 CALD1
caldesmon 1
chr10_+_5566923 1.584 NM_005185
CALML3
calmodulin-like 3
chr7_-_99277518 1.541 NM_000777
NM_001190484
CYP3A5

cytochrome P450, family 3, subfamily A, polypeptide 5

chr8_+_28559010 1.510 EXTL3
exostoses (multiple)-like 3
chr8_+_22022872 1.482 BMP1
bone morphogenetic protein 1
chr8_+_28559143 1.468 NM_001440
EXTL3
exostoses (multiple)-like 3
chr8_+_22022677 1.436 BMP1
bone morphogenetic protein 1
chr12_-_123201319 1.435 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chrX_+_44703248 1.388 NM_022076
DUSP21
dual specificity phosphatase 21
chr4_-_57522469 1.352 NM_001145459
NM_139211
HOPX

HOP homeobox

chr20_+_37555055 1.332 FAM83D
family with sequence similarity 83, member D
chr6_-_41130820 1.315 TREM2
triggering receptor expressed on myeloid cells 2
chr2_+_113875469 1.310 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr3_+_121774208 1.287 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr7_-_143991255 1.220 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr2_+_64681610 1.212 LGALSL
lectin, galactoside-binding-like
chr19_+_35645640 1.183 NM_144779
NM_001164605
FXYD5

FXYD domain containing ion transport regulator 5

chrX_+_99899388 1.175 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_-_48390873 1.169 NM_002900
RBP3
retinol binding protein 3, interstitial
chr3_-_139258373 1.146 RBP1
retinol binding protein 1, cellular
chr16_-_84651639 1.137 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr8_+_42752019 1.135 NM_032410
HOOK3
hook homolog 3 (Drosophila)
chr20_+_56285213 1.101


chr9_+_112542496 1.091 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chrX_+_99899162 1.077 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr6_+_34204928 1.058 HMGA1
high mobility group AT-hook 1
chr17_-_39274587 1.042 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr19_+_925984 1.007 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr20_+_43343884 1.005 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr22_+_37447615 1.004 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chrX_-_153602998 0.997 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr8_-_9008138 0.995 NM_024607
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr4_+_166248816 0.974 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr2_-_234652623 0.944 NM_001001394
DNAJB3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr2_+_158114109 0.937 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr4_+_89513597 0.932 NM_014606
HERC3
hect domain and RLD 3
chr16_+_31494438 0.910 NM_003041
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr10_+_102891060 0.906 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr22_+_45148437 0.904 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chr20_+_37554954 0.901 NM_030919
FAM83D
family with sequence similarity 83, member D
chr14_-_57272344 0.869 NM_172337
OTX2
orthodenticle homeobox 2
chr17_+_7905911 0.861 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr1_-_173837122 0.858 GAS5
growth arrest-specific 5 (non-protein coding)
chr6_+_34204690 0.853 HMGA1
high mobility group AT-hook 1
chr16_+_8806825 0.850 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr19_+_35646006 0.846 FXYD5
FXYD domain containing ion transport regulator 5
chr14_-_92198383 0.837 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr6_-_2840683 0.835 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr21_-_34960937 0.833 NM_017613
DONSON
downstream neighbor of SON
chr7_+_144052432 0.822 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr18_+_63417487 0.822 NM_033646
CDH7
cadherin 7, type 2
chr20_+_43344005 0.809 WISP2
WNT1 inducible signaling pathway protein 2
chrX_+_103357106 0.800 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chr1_-_155959860 0.780 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr12_+_105153258 0.771 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_43021605 0.765 CUL7
cullin 7
chr3_-_139258477 0.762 RBP1
retinol binding protein 1, cellular
chr15_-_74495528 0.733 NM_001142618
STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr8_+_22132809 0.723 NM_018068
PIWIL2
piwi-like 2 (Drosophila)
chr17_+_15848422 0.722 ADORA2B
adenosine A2b receptor
chr6_-_43021390 0.720 CUL7
cullin 7
chr15_-_74495093 0.717 NM_001199042
NM_022369
STRA6

stimulated by retinoic acid gene 6 homolog (mouse)

chr16_+_3096681 0.703 NM_022468
MMP25
matrix metallopeptidase 25
chr10_-_135090325 0.688 NM_001109
NM_001164489
NM_001164490
ADAM8


ADAM metallopeptidase domain 8


chr14_-_60632058 0.679 NM_016029
DHRS7
dehydrogenase/reductase (SDR family) member 7
chr11_-_66639602 0.679


chr2_+_102314162 0.674 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chrX_+_138612894 0.665 NM_000133
F9
coagulation factor IX
chr4_-_82126200 0.664 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr1_-_47655603 0.658 PDZK1IP1
PDZK1 interacting protein 1
chr11_-_121986800 0.650 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr19_-_54327428 0.642 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr3_-_56809594 0.642 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_+_53442732 0.633 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_+_47610244 0.628 FAM113B
family with sequence similarity 113, member B
chr22_-_36784001 0.603 MYH9
myosin, heavy chain 9, non-muscle
chr20_-_56284945 0.597 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_-_47655723 0.597 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr6_+_26087447 0.594 NM_000410
NM_139003
NM_139004
NM_139006
NM_139007
NM_139008
NM_139009
NM_139010
NM_139011
HFE








hemochromatosis








chrX_-_107682600 0.586 NM_001847
COL4A6
collagen, type IV, alpha 6
chr19_+_35645614 0.579 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_15197790 0.573 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr19_+_30863318 0.564 NM_014717
ZNF536
zinc finger protein 536
chr7_-_30066124 0.554 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr1_+_155146270 0.547 TRIM46
tripartite motif containing 46
chr6_-_30524950 0.542 GNL1
guanine nucleotide binding protein-like 1
chr11_-_2906960 0.542 NM_000076
NM_001122630
NM_001122631
CDKN1C


cyclin-dependent kinase inhibitor 1C (p57, Kip2)


chr11_+_117075682 0.541 TAGLN
transgelin
chr9_+_139560193 0.535 NM_201446
EGFL7
EGF-like-domain, multiple 7
chr2_-_37193609 0.534 NM_003162
STRN
striatin, calmodulin binding protein
chrX_-_107018889 0.529 TSC22D3
TSC22 domain family, member 3
chr19_+_2249112 0.526 NM_000479
AMH
anti-Mullerian hormone
chr10_+_124220990 0.519 NM_002775
HTRA1
HtrA serine peptidase 1
chr1_-_153085963 0.511 NM_001014450
SPRR2A
SPRR2F
small proline-rich protein 2A
small proline-rich protein 2F
chr13_-_53313924 0.508 NM_001011705
NM_007015
LECT1

leukocyte cell derived chemotaxin 1

chr9_-_35111534 0.507 FAM214B
family with sequence similarity 214, member B
chr2_-_133539627 0.506 NCKAP5
NCK-associated protein 5
chr4_-_103266286 0.503 NM_022154
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chrX_+_134124967 0.503 NM_001163438
CXorf69
chromosome X open reading frame 69
chr7_-_76038894 0.502 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr17_-_61777467 0.502 LIMD2
LIM domain containing 2
chr17_+_38375554 0.500 NM_133264
WIPF2
WAS/WASL interacting protein family, member 2
chrX_-_41782230 0.497 NM_001126054
NM_001126055
NM_003688
CASK


calcium/calmodulin-dependent serine protein kinase (MAGUK family)


chr3_-_149095517 0.495 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_-_57410275 0.494 NM_001178054
NM_013251
TAC3

tachykinin 3

chr22_+_42095502 0.479 NM_152513
MEI1
meiosis inhibitor 1
chr11_-_2162340 0.476 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_89746238 0.475 DUSP6
dual specificity phosphatase 6
chr1_-_231114596 0.469 TTC13
tetratricopeptide repeat domain 13
chr10_+_94352873 0.469 KIF11
kinesin family member 11
chr3_+_44916097 0.469 NM_003241
TGM4
transglutaminase 4 (prostate)
chr22_-_36783977 0.466 MYH9
myosin, heavy chain 9, non-muscle
chr3_-_71803923 0.464 NM_173359
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr14_-_23058062 0.463 DAD1
defender against cell death 1
chr8_-_42751622 0.463 NM_001160223
NM_001160224
NM_001160225
NM_030954
RNF170



ring finger protein 170



chr12_-_85306579 0.461 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr17_+_40169592 0.452 NM_001001349
NKIRAS2
NFKB inhibitor interacting Ras-like 2
chr14_+_95027760 0.449 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chrX_-_120100197 0.447 NM_001242922
NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A12
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A12
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr3_-_149095458 0.447 TM4SF1
transmembrane 4 L six family member 1
chr1_-_231114580 0.447 TTC13
tetratricopeptide repeat domain 13
chr22_+_27017927 0.446 NM_001886
CRYBA4
crystallin, beta A4
chr17_+_7387773 0.445 POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr11_-_2182408 0.443 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough
chr10_-_133795311 0.442 NM_004052
BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
chr2_-_113594325 0.438 NM_000576
IL1B
interleukin 1, beta
chrX_-_120085593 0.438 NM_001242922
NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A12
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A12
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr5_+_173472692 0.438 NM_015980
HMP19
HMP19 protein
chr3_-_149095413 0.437 TM4SF1
transmembrane 4 L six family member 1
chr14_-_53417636 0.436 FERMT2
fermitin family member 2
chr2_-_214016332 0.435 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chrX_-_120119637 0.435 NM_001080141
NM_001080146
CT47A11
CT47A6
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A1
chr19_+_9296269 0.431 NM_175883
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr6_-_43021630 0.431 NM_001168370
NM_014780
CUL7

cullin 7

chr1_-_205744543 0.428 NM_001135662
NM_001135663
NM_001135664
NM_003929
RAB7L1



RAB7, member RAS oncogene family-like 1



chr9_+_116356199 0.426 NM_144489
RGS3
regulator of G-protein signaling 3
chrX_-_118827116 0.423 SEPT6
septin 6
chr19_+_56154973 0.423 NM_016535
ZNF581
zinc finger protein 581
chr13_+_53035227 0.423 CKAP2
cytoskeleton associated protein 2
chr2_+_171673071 0.423 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr1_-_43424324 0.420 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chrX_-_120009778 0.418 NM_001145718
CT47B1
cancer/testis antigen family 47, member B1
chr6_-_43423785 0.418 NM_206539
DLK2
delta-like 2 homolog (Drosophila)
chr4_-_103266396 0.418 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr3_-_98241357 0.416 CLDND1
claudin domain containing 1
chr8_+_22133079 0.410 NM_001135721
PIWIL2
piwi-like 2 (Drosophila)
chr8_-_60031545 0.399 NM_014729
TOX
thymocyte selection-associated high mobility group box
chr5_-_33892292 0.395 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr7_+_102715580 0.393 ARMC10
armadillo repeat containing 10
chrX_+_134166318 0.392 NM_001078171
FAM127A
family with sequence similarity 127, member A
chr12_-_100378431 0.387 NM_152788
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr18_+_77623667 0.386 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr7_-_44105162 0.385 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr16_-_84651519 0.385 COTL1
coactosin-like 1 (Dictyostelium)
chr9_+_137218324 0.384 RXRA
retinoid X receptor, alpha
chr12_-_89746244 0.384 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr14_+_29236882 0.380 FOXG1
forkhead box G1
chr19_-_1132109 0.378 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr2_-_85581563 0.374 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr12_-_58160823 0.372 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr11_-_66488712 0.372 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr2_+_48541767 0.372 NM_002158
FOXN2
forkhead box N2
chr2_+_220436953 0.369 NM_002191
INHA
inhibin, alpha
chr11_+_129939667 0.368 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr7_+_102715616 0.368 ARMC10
armadillo repeat containing 10
chr11_+_117947785 0.368 TMPRSS4
transmembrane protease, serine 4
chr2_+_62900985 0.368 NM_001142615
EHBP1
EH domain binding protein 1
chr6_+_30525050 0.367 PRR3
proline rich 3
chr20_+_43343523 0.367 WISP2
WNT1 inducible signaling pathway protein 2
chr5_+_87564729 0.363 LOC100505894
uncharacterized LOC100505894
chr11_+_117947726 0.362 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr6_+_99872769 0.360


chr6_+_106546736 0.358 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_-_50847957 0.358 NAPSB
napsin B aspartic peptidase pseudogene
chrX_-_103174121 0.355 LOC100128594
uncharacterized LOC100128594
chr18_-_12656730 0.354 NM_001128627
SPIRE1
spire homolog 1 (Drosophila)
chr17_-_61777478 0.353 NM_030576
LIMD2
LIM domain containing 2
chr9_+_134165075 0.350 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr3_+_154798078 0.348 NM_007289
MME
membrane metallo-endopeptidase
chr7_-_143956720 0.347 NM_001005328
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chrX_-_120090453 0.347 NM_001080140
CT47A7
cancer/testis antigen family 47, member A7
chr17_-_39092714 0.344 KRT23
keratin 23 (histone deacetylase inducible)
chr4_+_77870864 0.342 NM_018243
SEPT11
septin 11
chr1_-_231114617 0.341 NM_001122835
NM_024525
TTC13

tetratricopeptide repeat domain 13

chr12_+_57828457 0.339 NM_005538
INHBC
inhibin, beta C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.43 9.90e-03 GO:0031347 regulation of defense response
2.06 2.21e-02 GO:0080134 regulation of response to stress

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.40 4.17e-03 GO:0015629 actin cytoskeleton
1.51 1.30e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.33 5.14e-03 GO:0003779 actin binding